CHEMBL476935


SMILES O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1
InChIKey ROKAKGMAWJNFEN-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 6
Molecular weight (Da) 360.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Pig 5-Hydroxytryptamine A pKi 6.36 6.36 6.36 ChEMBL
D4 DRD4 Rat Dopamine A pKi 7.76 7.76 7.76 ChEMBL
D1 DRD1 Pig Dopamine A pKi 6.47 6.47 6.47 ChEMBL
H1 HRH1 Human Histamine A pKi 6.8 6.8 6.8 ChEMBL
D4 DRD4 Human Dopamine A pKi 7.76 7.85 8.12 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.45 5.45 5.45 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.39 6.51 6.75 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.96 6.96 6.96 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.04 7.04 7.04 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.59 6.9 7.53 ChEMBL
D2 DRD2 Human Dopamine A pKd 7.55 7.55 7.55 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.45 5.45 5.45 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 6.6 6.6 6.6 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 7.76 7.76 7.77 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.04 7.04 7.04 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.96 6.96 6.96 PDSP Ki database
H1 HRH1 Human Histamine A pKi 6.8 6.8 6.8 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database