PGE2


SMILES CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O
InChIKey XEYBRNLFEZDVAW-ARSRFYASSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 12
Molecular weight (Da) 352.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Endogenous
Approved drug Yes

Database connections

Structure pdb 6AK3 7D7M 7CX2

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.7 7.7 7.7 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.6 6.7 6.8 Guide to Pharmacology
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 7.7 7.85 8.0 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.5 7.1 7.7 Guide to Pharmacology
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.8 7.0 7.2 Guide to Pharmacology
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 7.7 7.7 7.7 Guide to Pharmacology
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 6.7 6.75 6.8 Guide to Pharmacology
M5 ACM5 Rat Acetylcholine (muscarinic) A pKi 7.4 7.4 7.4 Guide to Pharmacology
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 7.4 7.65 7.9 Guide to Pharmacology
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.0 8.0 8.0 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 7.2 7.2 7.2 PDSP Ki database
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 7.22 7.64 8.14 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.46 7.9 8.38 PDSP Ki database
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 7.11 7.22 7.33 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.6 6.6 6.6 PDSP Ki database
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 6.92 7.11 7.3 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.85 7.85 7.85 PDSP Ki database
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 8.4 8.4 8.4 PDSP Ki database
M4 ACM4 Chicken Acetylcholine (muscarinic) A pKi 7.61 7.61 7.61 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database