CHEMBL4846823


SMILES CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O
InChIKey AKXPLUFJRRUGNE-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 5
Molecular weight (Da) 383.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.07 8.07 8.08 ChEMBL
D4 DRD4 Human Dopamine A pKi 7.32 7.32 7.32 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.84 5.84 5.84 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.7 6.7 6.7 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 9.13 9.13 9.13 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.96 5.96 5.96 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pIC50 7.0 7.0 7.0 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pEC50 8.56 8.56 8.56 ChEMBL