Irbesartan

Chemical Properties

SMILES CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight 428.2

Drug Properties

Type Small molecule
Endogenous No
Approved Yes
InChIKey YOSHYTLCDANDAN-UHFFFAOYSA-N

Bioactivity

Receptor Experimental Data Source
GTP Uniprot Species Family Class Type Min Avg Max Database
AT1 AGTR1 Human Angiotensin A pIC50 8.7 8.75 8.8 Guide to Pharmacology
AT1 AGTR1 Human Angiotensin A pKd 8.71 8.71 8.71 Guide to Pharmacology
AT1 AGTRB Rat Angiotensin A pKi 9.1 9.1 9.1 ChEMBL
AT1 AGTRB Rat Angiotensin A pIC50 8.89 8.89 8.89 ChEMBL
AT1 AGTR1 Human Angiotensin A pKi 8.7 8.91 9.1 ChEMBL
AT1 AGTR1 Human Angiotensin A pIC50 7.68 8.37 9.05 ChEMBL
ETA EDNRA Human Endothelin A pKi 5.0 5.0 5.0 ChEMBL