A-317920


SMILES O=C([C@H](NC(=O)c1ccco1)C)N1CCN(CC1)CCCOc1ccc(cc1)C(=O)C1CC1
InChIKey RTRADBQSZJIRMT-GOSISDBHSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 10
Molecular weight (Da) 453.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pKi 5.4 5.4 5.4 Guide to Pharmacology
H3 HRH3 Human Histamine A pKi 7.0 7.0 7.0 Guide to Pharmacology
H3 HRH3 Rat Histamine A pKi 9.2 9.2 9.2 Guide to Pharmacology
H3 HRH3 Rat Histamine A pKi 9.15 9.17 9.2 ChEMBL
H3 HRH3 Human Histamine A pKi 7.0 7.02 7.03 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database