CHEMBL520129


SMILES O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCCNC1
InChIKey NDTCTCKVFXXKQH-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 4
Molecular weight (Da) 434.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.75 5.75 5.75 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.24 5.24 5.24 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.89 8.89 8.89 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.76 6.76 6.76 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.25 5.25 5.25 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pIC50 8.0 8.0 8.0 ChEMBL