CHEMBL5221893


SMILES COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC
InChIKey YIKXMTAXJNUVDY-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Molecular weight (Da) 356.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 5.55 5.55 5.55 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.18 6.18 6.18 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 6.02 6.02 6.02 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.6 6.6 6.6 ChEMBL
β1 ADRB1 Human Adrenoceptors A pKi 6.02 6.02 6.02 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.28 6.28 6.28 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.25 7.25 7.25 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.17 6.17 6.17 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.61 5.61 5.61 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.86 5.86 5.86 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pEC50 7.96 7.98 8.0 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pEC50 7.69 7.7 7.7 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 7.4 7.41 7.41 ChEMBL