MK-7246


SMILES CN([C@@H]1CCc2c(CC(=O)O)c3ccccc3n2C1)S(=O)(=O)c1ccc(F)cc1
InChIKey JTCAGRAKUAAYDY-OAHLLOKOSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 416.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
DP1 PD2R Human Prostanoid A pKi 6.43 6.43 6.43 ChEMBL
DP2 PD2R2 Human Prostanoid A pKi 8.6 8.6 8.6 ChEMBL
TP TA2R Human Prostanoid A pKi 5.42 5.42 5.42 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.43 5.43 5.43 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
DP1 PD2R Human Prostanoid A pIC50 6.0 6.0 6.0 ChEMBL
DP2 PD2R2 Human Prostanoid A pIC50 7.7 8.46 8.66 ChEMBL