Nomifensine
Chemical Properties
| SMILES | CN1CC(C2=C(C1)C(=CC=C2)N)C3=CC=CC=C3 |
| Hydrogen bond acceptors | 2 |
| Hydrogen bond donors | 1 |
| Rotatable bonds | 1 |
| Molecular weight | 238.1 |
Drug Properties
| Type | Small molecule |
| Endogenous | No |
| Approved | No |
| InChIKey | XXPANQJNYNUNES-UHFFFAOYSA-N |
Bioactivity
| Receptor | Experimental Data | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| D1 | DRD1 | Human | Dopamine | A | pKi | 4.0 | 4.0 | 4.0 | PDSP KiDatabase |
| D2 | DRD2 | Human | Dopamine | A | pKi | 4.0 | 4.0 | 4.0 | PDSP KiDatabase |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 4.93 | 4.93 | 4.93 | PDSP KiDatabase |
| 5-HT2A | 5HT2A | Rat | 5-Hydroxytryptamine | A | pKi | 5.0 | 5.16 | 5.43 | PDSP KiDatabase |
| 5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 4.0 | 4.5 | 5.0 | PDSP KiDatabase |
| H1 | HRH1 | Rat | Histamine | A | pKi | 4.0 | 5.23 | 6.46 | PDSP KiDatabase |
| H1 | HRH1 | Human | Histamine | A | pKi | 4.57 | 4.57 | 4.57 | PDSP KiDatabase |
| D2 | DRD2 | Rat | Dopamine | A | pKi | 4.0 | 4.0 | 4.0 | PDSP KiDatabase |
| D1 | DRD1 | Rat | Dopamine | A | pKi | 4.0 | 4.0 | 4.0 | PDSP KiDatabase |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 4.0 | 4.0 | 4.0 | PDSP KiDatabase |