tegaserod
SMILES | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N |
InChIKey | IKBKZGMPCYNSLU-RGVLZGJSSA-N |
Chemical properties
Hydrogen bond acceptors | 3 |
Hydrogen bond donors | 3 |
Rotatable bonds | 7 |
Molecular weight (Da) | 301.2 |
Drug properties
Molecular type | Small molecule |
Endogenous/Surrogate | Surrogate |
Approved drug | No |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
5-HT4 | 5HT4R | Human | 5-Hydroxytryptamine | A | pKi | 7.51 | 8.22 | 8.4 | ChEMBL |
5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 8.4 | 8.4 | 8.4 | Guide to Pharmacology |
5-HT4 | 5HT4R | Human | 5-Hydroxytryptamine | A | pKi | 7.6 | 8.0 | 8.4 | Guide to Pharmacology |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
5-HT4 | 5HT4R | Human | 5-Hydroxytryptamine | A | pEC50 | 7.8 | 8.54 | 9.0 | ChEMBL |
CCR6 | CCR6 | Human | Chemokine | A | pIC50 | 4.63 | 4.63 | 4.63 | ChEMBL |
5-HT4 | 5HT4R | Guinea pig | 5-Hydroxytryptamine | A | pEC50 | 7.9 | 8.1 | 8.2 | ChEMBL |