GPCRdb

mosapride

SMILES	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl
InChIKey	YPELFRMCRYSPKZ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors	5
Hydrogen bond donors	2
Rotatable bonds	7
Molecular weight (Da)	421.2

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.72	6.72	6.72	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.18	8.18	8.18	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.68	6.68	6.68	ChEMBL
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pKi	8.16	8.16	8.16	Drug Central
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pKi	6.2	6.55	6.9	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.23	8.23	8.23	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.86	5.86	5.86	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.06	6.06	6.06	ChEMBL

Showing 1 to 10 of 10 entries

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.53	6.53	6.53	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	6.4	6.4	6.4	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.43	5.43	5.43	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	5.72	5.72	5.72	ChEMBL

Showing 1 to 4 of 4 entries