GPCRdb

mosapride

Agent/drug
Bioactivity

mosapride

SMILES	CCOc1cc(N)c(Cl)cc1C(=O)NCC1CN(Cc2ccc(F)cc2)CCO1
InChIKey	YPELFRMCRYSPKZ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	2
Rotatable bonds	7
Molecular weight (Da)	421.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.86	5.86	5.86	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.23	8.23	8.23	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.06	6.06	6.06	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.72	6.72	6.72	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.68	6.68	6.68	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.18	8.18	8.18	Drug Central
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pKi	6.20	6.55	6.90	Guide to Pharmacology
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pKi	8.16	8.16	8.16	Drug Central
5-HT₄	5HT4R	Guinea pig	5-Hydroxytryptamine	A	pKi	8.15	8.15	8.15	Drug Central

Showing 1 to 11 of 11 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.43	5.43	5.43	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	5.72	5.72	5.72	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.53	6.53	6.53	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	6.40	6.40	6.40	ChEMBL

Showing 1 to 4 of 4 entries

mosapride

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 2

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Diseases of the digestive system, unspecified	DE2Z	A03F	0.520	4	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Dyspepsia	MD92	A03F	0.400	3	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Gastritis, unspecified	DA42.Z	A03F	0.037	4	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Irritable bowel syndrome, type unspecified	DD91.0Z	A03F	0.538	4	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Paralytic ileus	DA93.0	A03F	0.400	3	Yes

Showing 1 to 5 of 5 entries