methoctramine


SMILES COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC
InChIKey RPMBYDYUVKEZJA-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 29
Molecular weight (Da) 582.5

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations M1

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Fruit fly Acetylcholine (muscarinic) A pKi 5.41 5.47 5.54 ChEMBL
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 7.49 7.55 7.58 ChEMBL
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 5.96 5.98 6.02 ChEMBL
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 7.7 7.81 7.84 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 7.38 7.42 7.43 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.26 6.38 6.5 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.97 7.2 7.42 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 6.28 6.42 6.56 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKd 7.71 7.84 7.92 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 7.44 8.04 9.22 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKd 6.85 6.85 6.85 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.08 7.19 7.3 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 7.11 7.76 8.44 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.51 7.05 7.3 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.6 6.95 7.3 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 7.3 7.85 8.4 Guide to Pharmacology
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 6.56 6.71 6.93 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 6.1 6.5 6.9 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.14 7.52 8.09 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.6 7.05 7.5 Guide to Pharmacology
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.5 6.87 7.24 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.3 6.75 7.2 Guide to Pharmacology
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 6.39 7.32 8.99 PDSP Ki database
M4 ACM4 Mouse Acetylcholine (muscarinic) A pKi 6.8 6.8 6.8 PDSP Ki database
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 7.31 7.74 8.34 PDSP Ki database
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 7.3 7.3 7.3 Guide to Pharmacology
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 6.22 7.24 7.8 PDSP Ki database
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 7.8 7.8 7.8 Guide to Pharmacology
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 5.52 6.1 6.88 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M2 ACM2 Pig Acetylcholine (muscarinic) A pEC50 5.52 5.52 5.52 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 5.45 5.75 6.05 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 7.29 7.5 7.66 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 5.8 5.8 5.8 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 4.9 4.9 4.9 ChEMBL