Naltrexone


SMILES O=C1CC[C@@]2([C@@]34[C@H]1Oc1c4c(C[C@H]2N(CC3)CC2CC2)ccc1O)O
InChIKey DQCKKXVULJGBQN-XFWGSAIBSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 341.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Bioactivity

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Human Opioid A pKi 8.0 8.0 8.0 Guide to Pharmacology
δ OPRD Mouse Opioid A pKi 6.8 6.8 6.8 Guide to Pharmacology
κ OPRK Human Opioid A pKi 8.4 8.9 9.4 Guide to Pharmacology
κ OPRK Mouse Opioid A pIC50 9.2 9.2 9.2 Guide to Pharmacology
μ OPRM Human Opioid A pKi 9.15 9.42 9.7 Guide to Pharmacology
κ OPRK Mouse Opioid A pKd 7.74 7.74 7.74 ChEMBL
κ OPRK Mouse Opioid A pKi 8.84 8.84 8.84 ChEMBL
κ OPRK Mouse Opioid A pEC50 9.09 9.09 9.09 ChEMBL
κ OPRK Rat Opioid A pKi 7.9 8.5 8.97 ChEMBL
μ OPRM Mouse Opioid A pKd 8.76 8.76 8.76 ChEMBL
μ OPRM Mouse Opioid A pKi 8.31 9.28 9.58 ChEMBL
μ OPRM Mouse Opioid A pEC50 9.8 9.8 9.8 ChEMBL
μ OPRM Mouse Opioid A pIC50 7.99 7.99 7.99 ChEMBL
δ OPRD Mouse Opioid A pKi 6.84 7.24 7.91 ChEMBL
δ OPRD Mouse Opioid A pKd 7.41 7.41 7.41 ChEMBL
δ OPRD Mouse Opioid A pEC50 8.36 8.36 8.36 ChEMBL
δ OPRD Rat Opioid A pKi 7.0 7.56 8.32 ChEMBL
δ OPRD Rat Opioid A pIC50 6.66 7.46 8.25 ChEMBL
κ OPRK Guinea pig Opioid A pKi 7.36 8.57 9.51 ChEMBL
κ OPRK Guinea pig Opioid A pIC50 7.33 8.31 9.3 ChEMBL
μ OPRM Rat Opioid A pKi 8.59 8.88 9.34 ChEMBL
μ OPRM Rat Opioid A pIC50 8.17 8.46 8.82 ChEMBL
δ OPRD Human Opioid A pKi 6.93 7.65 8.2 ChEMBL
δ OPRD Human Opioid A pIC50 6.6 7.63 8.26 ChEMBL
δ OPRD Human Opioid A pEC50 7.68 8.14 8.36 ChEMBL
δ OPRD Human Opioid A pKd 8.8 8.8 8.8 ChEMBL
κ OPRK Human Opioid A pKi 8.0 9.04 10.38 ChEMBL
κ OPRK Human Opioid A pEC50 8.48 8.77 9.09 ChEMBL
κ OPRK Human Opioid A pIC50 6.7 7.37 8.73 ChEMBL
μ OPRM Human Opioid A pKi 8.44 9.41 10.15 ChEMBL
μ OPRM Human Opioid A pEC50 7.8 8.82 9.42 ChEMBL
μ OPRM Human Opioid A pIC50 7.77 8.28 9.23 ChEMBL
μ OPRM Human Opioid A pKd 10.3 10.3 10.3 ChEMBL
μ OPRM Human Opioid A pKi 7.03 7.03 7.03 Drug Central
κ OPRK Human Opioid A pKi 7.05 7.05 7.05 Drug Central
δ OPRD Human Opioid A pKi 7.1 7.1 7.1 Drug Central
μ OPRM Rat Opioid A pKi 7.03 7.03 7.03 Drug Central
μ OPRM Mouse Opioid A pKi 7.02 7.02 7.02 Drug Central
δ OPRD Mouse Opioid A pKi 7.1 7.1 7.1 Drug Central
δ OPRD Rat Opioid A pKi 7.08 7.08 7.08 Drug Central
κ OPRK Guinea pig Opioid A pKi 7.02 7.02 7.02 Drug Central
κ OPRK Rat Opioid A pKi 7.05 7.05 7.05 Drug Central
κ OPRK Mouse Opioid A pKi 7.05 7.05 7.05 Drug Central