MPEP


SMILES Cc1cccc(n1)C#Cc1ccccc1
InChIKey NEWKHUASLBMWRE-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 0
Molecular weight (Da) 193.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations mGlu4 mGlu5

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Human Metabotropic glutamate C pKi 4.52 5.98 7.44 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 7.68 7.93 8.33 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 7.44 7.92 8.47 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKd 8.07 8.07 8.07 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 7.55 7.98 8.48 PDSP Ki database
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 7.41 8.09 9.52 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu4 GRM4 Human Metabotropic glutamate C pEC50 6.3 6.45 6.6 Guide to Pharmacology
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 7.4 7.55 7.7 Guide to Pharmacology
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.7 4.9 5.1 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 7.05 8.06 9.7 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 7.41 7.89 8.82 ChEMBL