GPCRdb

olanzapine

Agent/drug
Bioactivity

olanzapine

SMILES	Cc1cc2c(s1)=Nc1ccccc1NC=2N1CCN(C)CC1
InChIKey	WXPNDRBBWZMPQG-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	1
Rotatable bonds	1
Molecular weight (Da)	312.1

Database connections

PubChem Guide To Pharmacology DrugBank ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	5-HT_1A 5-HT_2C 5-HT₇ D₂ D₄

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.58	7.59	7.60	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	6.00	6.81	7.22	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	7.16	7.42	7.68	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	6.00	6.00	6.00	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	6.58	6.58	6.58	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.18	8.18	8.18	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.35	7.35	7.35	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.94	7.04	7.22	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.00	6.47	6.72	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.33	6.51	6.72	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.72	6.86	7.00	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.74	6.97	7.09	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.15	8.15	8.15	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.00	7.07	7.11	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.68	7.21	7.54	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central

Showing 1 to 20 of 155 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	7.19	7.19	7.19	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.14	8.14	8.14	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pA2	7.40	7.40	7.40	Guide to Pharmacology
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	7.43	7.43	7.43	ChEMBL
α_1D	ADA1D	Rat	Adrenoceptors	A	pA2	6.40	6.40	6.40	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	7.04	7.04	7.04	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.27	6.27	6.27	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	6.38	6.38	6.38	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	6.28	6.28	6.28	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	6.15	6.15	6.15	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	7.00	7.88	8.30	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	7.24	7.24	7.24	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	7.15	7.42	7.68	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	7.89	7.89	7.89	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	7.14	7.14	7.14	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	6.80	6.80	6.80	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	6.93	7.46	8.00	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	7.11	7.11	7.11	ChEMBL
D₄	DRD4	Human	Dopamine	A	pIC50	6.76	6.76	6.76	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	7.89	7.89	7.89	ChEMBL

Showing 1 to 20 of 24 entries

olanzapine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 10

Phase II 28

Phase III 51

Approved Yes

Database connections

PubChem Guide To Pharmacology DrugBank ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	5-HT_1A 5-HT_2C 5-HT₇ D₂ D₄

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Alcohol dependence, unspecified	6C40.2Z	N05A	0.268	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Anorexia	MG43.7	N05A	0.293	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Anorexia Nervosa, unspecified	6B80.Z	N05A	0.508	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Autism spectrum disorder, unspecified	6A02.Z	N05A	0.462	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	N05A	0.609	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Delirium, unspecified or unknown cause	6D70.Z	N05A	0.588	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N05A	0.607	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Disorders due to use of opioids, unspecified	6C43.Z	N05A	0.108	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Disorders of intellectual development, unspecified	6A00.Z	N05A	0.360	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Excessive weight loss	MG43.5	N05A	0.083	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Gambling disorder, unspecified	6C50.Z	N05A	0.259	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Huntington disease	8A01.10	N05A	0.275	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Hypoalphalipoproteinaemia	5C81.0	N05A	0.054	1	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Mood disorders, unspecified	6A8Z	N05A	0.490	1	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Nausea	MD90.0	N05A	0.337	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Nausea or vomiting	MD90	N05A	0.543	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Other specified depressive disorders	6A7Y	N05A	0.552	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Personality disorder, severity unspecified	6D10.Z	N05A	0.507	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Restlessness	MB24.F	N05A	0.602	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizoaffective disorder, unspecified	6A21.Z	N05A	0.606	4	Yes

Showing 1 to 20 of 120 entries

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olanzapine

olanzapine

Chemical Properties

Database connections

Bioactivities

olanzapine

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information