afamelanotide
SMILES | None |
InChIKey | UAHFGYDRQSXQEB-LEBBXHLNSA-N |
Sequence | SYSXEHFRWGKPV |
Chemical properties
Hydrogen bond acceptors | None |
Hydrogen bond donors | None |
Rotatable bonds | None |
Molecular weight (Da) |
Drug properties
Molecular type | Peptide |
Endogenous/Surrogate | Surrogate |
Approved drug | Yes |
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
MC3 | MC3R | Human | Melanocortin | A | pKi | 8.9 | 8.9 | 8.9 | Guide to Pharmacology |
MC4 | MC4R | Human | Melanocortin | A | pKi | 8.5 | 8.65 | 8.8 | Guide to Pharmacology |
MC4 | MC4R | Human | Melanocortin | A | pKi | 7.72 | 9.0 | 9.52 | ChEMBL |
MC1 | MSHR | Human | Melanocortin | A | pKi | 8.74 | 9.46 | 10.34 | ChEMBL |
MC3 | MC3R | Human | Melanocortin | A | pKi | 9.11 | 9.14 | 9.17 | ChEMBL |
MC5 | MC5R | Human | Melanocortin | A | pKi | 8.0 | 8.66 | 9.32 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
MC1 | MSHR | Human | Melanocortin | A | pIC50 | 10.0 | 10.0 | 10.0 | Guide to Pharmacology |
MC5 | MC5R | Human | Melanocortin | A | pIC50 | 9.0 | 9.0 | 9.0 | Guide to Pharmacology |
MC1 | MSHR | Mouse | Melanocortin | A | pEC50 | 7.92 | 10.38 | 11.0 | ChEMBL |
MC1 | MSHR | Mouse | Melanocortin | A | pIC50 | 9.51 | 9.52 | 9.54 | ChEMBL |
MC4 | MC4R | Human | Melanocortin | A | pIC50 | 7.85 | 8.96 | 9.82 | ChEMBL |
MC4 | MC4R | Human | Melanocortin | A | pEC50 | 8.05 | 9.27 | 10.77 | ChEMBL |
MC3 | MC3R | Mouse | Melanocortin | A | pEC50 | 7.12 | 9.76 | 10.2 | ChEMBL |
MC3 | MC3R | Mouse | Melanocortin | A | pIC50 | 8.09 | 8.25 | 8.38 | ChEMBL |
MC4 | MC4R | Mouse | Melanocortin | A | pEC50 | 6.92 | 9.42 | 10.01 | ChEMBL |
MC4 | MC4R | Mouse | Melanocortin | A | pIC50 | 8.38 | 8.73 | 8.96 | ChEMBL |
MC5 | MC5R | Mouse | Melanocortin | A | pEC50 | 6.77 | 9.71 | 10.52 | ChEMBL |
MC5 | MC5R | Mouse | Melanocortin | A | pIC50 | 6.85 | 6.85 | 6.85 | ChEMBL |
MC1 | MSHR | Human | Melanocortin | A | pEC50 | 9.3 | 9.95 | 10.64 | ChEMBL |
MC1 | MSHR | Human | Melanocortin | A | pIC50 | 9.29 | 9.29 | 9.29 | ChEMBL |
MC3 | MC3R | Human | Melanocortin | A | pEC50 | 8.17 | 9.15 | 9.89 | ChEMBL |
MC3 | MC3R | Human | Melanocortin | A | pIC50 | 8.42 | 8.63 | 8.93 | ChEMBL |
MC5 | MC5R | Human | Melanocortin | A | pIC50 | 8.66 | 8.9 | 9.07 | ChEMBL |
MC5 | MC5R | Human | Melanocortin | A | pEC50 | 8.96 | 9.21 | 9.64 | ChEMBL |
MC3 | MC3R | Rat | Melanocortin | A | pEC50 | 10.0 | 10.0 | 10.0 | ChEMBL |