GPCRdb

perphenazine

Agent/drug
Bioactivity

perphenazine

SMILES	OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1
InChIKey	RGCVKNLCSQQDEP-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	1
Rotatable bonds	6
Molecular weight (Da)	403.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.10	8.10	8.10	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.00	8.00	8.00	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.09	6.09	6.09	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.98	6.98	6.98	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.07	7.07	7.07	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.15	8.15	8.15	Drug Central
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.70	6.04	6.38	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.22	8.22	8.22	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.20	8.20	8.20	Guide to Pharmacology
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.25	8.25	8.25	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.08	8.08	8.08	Drug Central
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	6.88	7.09	7.30	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.88	6.88	6.88	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.16	8.16	8.16	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.90	6.90	6.90	Guide to Pharmacology
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	7.10	7.10	7.10	Guide to Pharmacology
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	7.80	7.80	7.80	Guide to Pharmacology
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	7.77	7.79	7.80	PDSP Ki database

Showing 1 to 20 of 47 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.56	5.56	5.56	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pIC50	5.56	5.56	5.56	ChEMBL
apelin	APJ	Human	Apelin	A	pIC50	5.49	5.49	5.49	ChEMBL
CX₃CR1	CX3C1	Human	Chemokine	A	pIC50	5.53	5.53	5.53	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	9.52	9.52	9.52	ChEMBL
FPR1	FPR1	Human	Formylpeptide	A	pIC50	5.32	5.32	5.32	ChEMBL
FPR3	FPR3	Human	Formylpeptide	A	pIC50	5.21	5.21	5.21	ChEMBL
GLP-1	GLP1R	Human	Glucagon	B1	pIC50	5.41	5.41	5.41	ChEMBL
GPR119	GP119	Human	GPR18, GPR55 and GPR119	A	pIC50	5.29	5.29	5.29	ChEMBL
GPR183	GP183	Human	A orphans	A	pIC50	5.38	5.38	5.38	ChEMBL
GPR35	GPR35	Human	A orphans	A	pIC50	5.22	5.22	5.22	ChEMBL
GPR65	PSYR	Human	A orphans	A	pIC50	5.40	5.40	5.40	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.70	4.83	4.95	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	4.60	4.80	5.00	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.80	4.80	4.80	ChEMBL

Showing 1 to 15 of 15 entries

perphenazine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 2

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z	N05A	0.374	4	Yes
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.508	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Nausea or vomiting	MD90	N05A	0.573	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Restlessness	MB24.F	N05A	0.602	3	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z	N05A	0.615	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.732	4	Yes

Showing 1 to 6 of 6 entries