GPCRdb

PF-514273

Agent/drug
Bioactivity

PF-514273

SMILES	CC(F)(F)CN1CCOc2c(nn(-c3ccccc3Cl)c2-c2ccc(Cl)cc2)C1=O
InChIKey	FJMQJSUOOGOWBD-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	0
Rotatable bonds	4
Molecular weight (Da)	451.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

CB₁	CNR1	Human	Cannabinoid	A	pKi	9.09	9.09	9.09	Guide to Pharmacology
CB₁	CNR1	Human	Cannabinoid	A	pKi	9.00	9.04	9.09	ChEMBL
CB₁	CNR1	Human	Cannabinoid	A	pKi	9.00	9.04	9.09	PDSP Ki database
CB₂	CNR2	Human	Cannabinoid	A	pKi	5.00	5.00	5.00	PDSP Ki database

Showing 1 to 4 of 4 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pEC50	5.97	5.97	5.97	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pEC50	5.84	5.84	5.84	ChEMBL
ADGRF1	AGRF1	Human	ADGRF	B2	pEC50	5.69	5.69	5.69	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pEC50	5.90	5.90	5.90	ChEMBL
CX₃CR1	CX3C1	Human	Chemokine	A	pEC50	4.75	4.75	4.75	ChEMBL
FFA4	FFAR4	Human	Free fatty acid	A	pEC50	5.92	5.92	5.92	ChEMBL
GLP-1	GLP1R	Human	Glucagon	B1	pEC50	5.64	5.64	5.64	ChEMBL
GPR119	GP119	Human	GPR18, GPR55 and GPR119	A	pEC50	6.26	6.26	6.26	ChEMBL

Showing 1 to 8 of 8 entries

PF-514273

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Compound is not listed as a drug.