O-DESMETHYL TRAMADOL


SMILES CN(C)C[C@H]1CCCC[C@]1(O)c1cccc(O)c1
InChIKey UWJUQVWARXYRCG-HIFRSBDPSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Molecular weight (Da) 249.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Rat Opioid A pKi 7.89 7.89 7.89 ChEMBL
δ OPRD Human Opioid A pKi 5.54 5.54 5.54 ChEMBL
κ OPRK Human Opioid A pKi 6.35 6.35 6.35 ChEMBL
μ OPRM Human Opioid A pKi 7.89 7.97 8.07 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Rat Opioid A pEC50 6.61 6.61 6.61 ChEMBL
μ OPRM Human Opioid A pIC50 7.33 7.34 7.37 ChEMBL
μ OPRM Human Opioid A pEC50 6.62 6.77 6.92 ChEMBL