GPCRdb

pimozide

Agent/drug
Bioactivity

pimozide

SMILES	O=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
InChIKey	YVUQSNJEYSNKRX-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	1
Rotatable bonds	7
Molecular weight (Da)	461.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	D₂

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.17	8.17	8.17	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.70	6.70	6.70	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.24	8.24	8.24	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.80	5.80	5.80	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.09	6.09	6.09	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.42	6.42	6.42	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.80	6.80	6.80	Guide to Pharmacology
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.19	6.46	7.06	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.18	8.18	8.18	Drug Central
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.51	5.51	5.51	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	8.26	8.26	8.26	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.10	7.40	7.70	Guide to Pharmacology
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.11	7.52	7.84	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.12	8.12	8.12	Drug Central
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.26	5.80	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.47	5.92	6.24	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.22	8.22	8.22	Drug Central
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	7.20	7.20	7.20	Guide to Pharmacology

Showing 1 to 20 of 63 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

δ	OPRD	Human	Opioid	A	pIC50	8.27	8.27	8.27	Drug Central
δ	OPRD	Human	Opioid	A	pIC50	5.42	5.42	5.42	ChEMBL
κ	OPRK	Human	Opioid	A	pIC50	6.00	6.00	6.00	ChEMBL
κ	OPRK	Human	Opioid	A	pIC50	8.22	8.22	8.22	Drug Central
μ	OPRM	Human	Opioid	A	pIC50	6.43	6.43	6.43	ChEMBL
μ	OPRM	Human	Opioid	A	pIC50	8.19	8.19	8.19	Drug Central
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.80	4.92	5.05	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	4.90	5.05	5.20	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.50	4.50	4.50	ChEMBL

Showing 1 to 9 of 9 entries

pimozide

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 12

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	D₂

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Amyotrophic lateral sclerosis	8B60.0	N05A	0.108	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.620	2	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Tourette syndrome	8A05.00	N05A	0.593	4	Yes
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	Class A	Amyotrophic lateral sclerosis	8B60.0	N05A	0.092	2	Yes
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.508	2	Yes
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	Class A	Tourette syndrome	8A05.00	N05A	0.481	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Amyotrophic lateral sclerosis	8B60.0	N05A	0.111	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.732	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Tourette syndrome	8A05.00	N05A	0.648	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Amyotrophic lateral sclerosis	8B60.0	N05A	0.106	2	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.704	2	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Tourette syndrome	8A05.00	N05A	0.537	4	Yes
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	Class A	Amyotrophic lateral sclerosis	8B60.0	N05A	0.105	2	Yes
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.619	2	Yes
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	Class A	Tourette syndrome	8A05.00	N05A	0.530	4	Yes
DRD5	D₅ receptor	Dopamine receptors	Aminergic receptors	Class A	Amyotrophic lateral sclerosis	8B60.0	N05A	0.092	2	Yes
DRD5	D₅ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.528	2	Yes
DRD5	D₅ receptor	Dopamine receptors	Aminergic receptors	Class A	Tourette syndrome	8A05.00	N05A	0.390	4	Yes

Showing 1 to 18 of 18 entries

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pimozide

pimozide

Chemical Properties

Database connections

Bioactivities

pimozide

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information