GPCRdb

PPTN

Agent/drug
Bioactivity

PPTN

SMILES	O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1
InChIKey	FOECKIWHCOYYFL-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	2
Rotatable bonds	4
Molecular weight (Da)	475.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.49	5.49	5.49	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.82	5.82	5.82	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.59	5.59	5.59	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.00	6.00	6.00	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pKi	5.14	5.40	5.54	ChEMBL
δ	OPRD	Human	Opioid	A	pKi	5.56	5.56	5.56	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	5.49	5.49	5.49	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.40	5.50	5.60	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.94	5.94	5.94	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.92	5.92	5.92	ChEMBL
5-HT_5A	5HT5A	Human	5-Hydroxytryptamine	A	pKi	5.62	5.62	5.62	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	5.48	5.48	5.48	ChEMBL
CysLT₁	CLTR1	Human	Leukotriene	A	pKi	6.64	6.64	6.64	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	5.00	5.00	5.00	ChEMBL
D₃	DRD3	Rat	Dopamine	A	pKi	5.17	5.17	5.17	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	5.17	5.78	6.05	ChEMBL
D₅	DRD5	Human	Dopamine	A	pKi	5.55	5.69	5.98	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pKi	5.66	5.66	5.66	ChEMBL
NTS₁	NTR1	Human	Neurotensin	A	pKi	5.16	5.16	5.16	ChEMBL
P2Y₁₄	P2Y14	Human	P2Y	A	pKi	10.10	10.10	10.10	Guide to Pharmacology

Showing 1 to 20 of 23 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.39	5.39	5.39	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	5.16	5.16	5.16	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pIC50	5.36	5.36	5.36	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pIC50	5.02	5.02	5.02	ChEMBL
κ	OPRK	Human	Opioid	A	pIC50	5.09	5.09	5.09	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pIC50	5.15	5.15	5.15	ChEMBL
ADGRF1	AGRF1	Human	ADGRF	B2	pIC50	5.49	5.49	5.49	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pIC50	5.20	5.20	5.20	ChEMBL
CysLT₁	CLTR1	Human	Leukotriene	A	pIC50	6.25	6.25	6.25	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	5.10	5.10	5.10	ChEMBL
EP₃	PE2R3	Human	Prostanoid	A	pIC50	5.03	5.03	5.03	ChEMBL
FPR1	FPR1	Human	Formylpeptide	A	pIC50	5.25	5.25	5.25	ChEMBL
FPR3	FPR3	Human	Formylpeptide	A	pIC50	5.42	5.42	5.42	ChEMBL
GPR119	GP119	Human	GPR18, GPR55 and GPR119	A	pIC50	5.47	5.47	5.47	ChEMBL
GPR183	GP183	Human	A orphans	A	pIC50	5.36	5.36	5.36	ChEMBL
GPR35	GPR35	Human	A orphans	A	pIC50	5.44	5.44	5.44	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	5.38	5.38	5.38	ChEMBL
NTS₁	NTR1	Human	Neurotensin	A	pIC50	5.06	5.06	5.06	ChEMBL
P2Y₁₄	P2Y14	Mouse	P2Y	A	pIC50	7.67	7.67	7.67	ChEMBL
P2Y₁₄	P2Y14	Human	P2Y	A	pIC50	7.72	8.55	9.40	ChEMBL

Showing 1 to 20 of 21 entries

PPTN

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Compound is not listed as a drug.