GPCRdb

prucalopride

Agent/drug
Bioactivity

prucalopride

SMILES	COCCCN1CCC(NC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1
InChIKey	ZPMNHBXQOOVQJL-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	2
Rotatable bonds	6
Molecular weight (Da)	367.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
β₃	ADRB3	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
δ	OPRD	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
κ	OPRK	Guinea pig	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
μ	OPRM	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pKi	7.00	7.80	8.60	Guide to Pharmacology
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pKi	6.96	7.89	8.60	ChEMBL
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pKd	8.70	8.70	8.70	ChEMBL

Showing 1 to 20 of 38 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT₄	5HT4R	Rat	5-Hydroxytryptamine	A	pEC50	7.58	7.58	7.58	ChEMBL
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pEC50	7.58	8.05	8.28	ChEMBL
5-HT₄	5HT4R	Rat	5-Hydroxytryptamine	A	pEC50	8.12	8.12	8.12	Drug Central

Showing 1 to 3 of 3 entries

prucalopride

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 2

Phase III 2

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Constipation	ME05.0	A06A	0.590	4	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Dyspepsia	MD92	A06A	0.400	2	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Dysphagia	MD93	A06A	0.074	2	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Functional gastrointestinal disorders, unspecified	DD9Z	A06A	0.526	4	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Irritable bowel syndrome, type unspecified	DD91.0Z	A06A	0.538	3	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Paralytic ileus	DA93.0	A06A	0.400	3	Yes

Showing 1 to 6 of 6 entries