GPCRdb

ropinirole

Agent/drug
Bioactivity

ropinirole

SMILES	CCCN(CCC)CCc1cccc2c1CC(O)=N2
InChIKey	UHSKFQJFRQCDBE-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	7
Molecular weight (Da)	260.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.73	5.73	5.73	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.24	8.24	8.24	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.12	6.12	6.12	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.92	5.92	5.92	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.23	8.23	8.23	Drug Central
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.77	5.77	5.77	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.54	6.54	6.54	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.18	8.18	8.18	Drug Central
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.86	5.86	5.86	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	8.23	8.23	8.23	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	5.42	5.42	5.42	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.27	8.27	8.27	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database

Showing 1 to 20 of 48 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pEC50	6.85	6.85	6.85	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pEC50	8.16	8.16	8.16	Drug Central
D₂	DRD2	Bovine	Dopamine	A	pIC50	5.17	5.17	5.17	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	5.74	5.74	5.74	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pEC50	7.12	7.12	7.12	ChEMBL
D₂	DRD2	Human	Dopamine	A	pEC50	6.48	6.87	8.19	ChEMBL
D₂	DRD2	Bovine	Dopamine	A	pIC50	8.29	8.29	8.29	Drug Central
D₃	DRD3	Rat	Dopamine	A	pIC50	6.97	6.97	6.97	ChEMBL
D₃	DRD3	Human	Dopamine	A	pEC50	7.72	8.03	8.40	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.75	4.80	4.85	ChEMBL

Showing 1 to 10 of 10 entries

ropinirole

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 3

Phase II 12

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Chronic widespread pain	MG30.01	N04B	0.517	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Cocaine dependence, unspecified	6C45.2Z	N04B	0.470	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Hyperprolactinaemia	5A60.1	N04B	0.567	1	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Parkinson disease, unspecified	8A00.0Z	N04B	0.621	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Progressive myoclonic epilepsy	8A61.41	N04B	0.074	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Restless legs syndrome	7A80	N04B	0.600	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Stroke not known if ischaemic or haemorrhagic	8B20	N04B	0.093	2	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Chronic widespread pain	MG30.01	N04B	0.103	2	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Cocaine dependence, unspecified	6C45.2Z	N04B	0.304	2	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Hyperprolactinaemia	5A60.1	N04B	0.552	1	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Parkinson disease, unspecified	8A00.0Z	N04B	0.612	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Progressive myoclonic epilepsy	8A61.41	N04B	0.074	2	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Restless legs syndrome	7A80	N04B	0.600	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Stroke not known if ischaemic or haemorrhagic	8B20	N04B	0.514	2	Yes
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	Class A	Chronic widespread pain	MG30.01	N04B	0.102	2	Yes
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	Class A	Cocaine dependence, unspecified	6C45.2Z	N04B	0.292	2	Yes
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	Class A	Hyperprolactinaemia	5A60.1	N04B	0.552	1	Yes
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	Class A	Parkinson disease, unspecified	8A00.0Z	N04B	0.609	4	Yes
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	Class A	Progressive myoclonic epilepsy	8A61.41	N04B	0.074	2	Yes
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	Class A	Restless legs syndrome	7A80	N04B	0.599	4	Yes

Showing 1 to 20 of 21 entries

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ropinirole

ropinirole

Chemical Properties

Database connections

Bioactivities

ropinirole

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information