aripiprazole


SMILES O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl
InChIKey CEUORZQYGODEFX-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 447.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 7E2Z 7VOE
Ligand site mutations 5-HT2A D2 D4

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 4.2 4.2 4.2 Guide to Pharmacology
mGlu7 GRM7 Human Metabotropic glutamate C pKi 3.05 3.05 3.05 Guide to Pharmacology
mGlu3 GRM3 Rat Metabotropic glutamate C pKi 4.8 4.8 4.8 Guide to Pharmacology
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 5.0 5.2 5.4 Guide to Pharmacology
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 5.5 5.8 6.1 Guide to Pharmacology
mGlu6 GRM6 Human Metabotropic glutamate C pKi 4.22 4.22 4.22 ChEMBL
mGlu1 GRM1 Human Metabotropic glutamate C pKi 4.38 4.38 4.38 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pKi 5.3 5.3 5.3 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pKi 4.7 4.7 4.7 Guide to Pharmacology
mGlu4 GRM4 Human Metabotropic glutamate C pKi 4.01 4.01 4.01 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 4.82 4.82 4.82 ChEMBL
mGlu8 GRM8 Human Metabotropic glutamate C pKi 4.35 4.35 4.35 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu6 GRM6 Human Metabotropic glutamate C pEC50 4.7 4.7 4.7 Guide to Pharmacology
mGlu8 GRM8 Human Metabotropic glutamate C pEC50 4.4 4.4 4.4 Guide to Pharmacology
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 5.7 5.7 5.7 Guide to Pharmacology
mGlu6 GRM6 Rat Metabotropic glutamate C pEC50 4.2 4.2 4.2 Guide to Pharmacology
mGlu8 GRM8 Rat Metabotropic glutamate C pEC50 4.3 4.3 4.3 Guide to Pharmacology
mGlu6 GRM6 Rat Metabotropic glutamate C pEC50 4.22 4.22 4.22 ChEMBL
mGlu6 GRM6 Human Metabotropic glutamate C pEC50 4.09 4.09 4.09 ChEMBL
mGlu1 GRM1 Human Metabotropic glutamate C pEC50 4.66 4.84 5.03 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 4.75 5.12 5.7 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pEC50 4.52 4.52 4.52 ChEMBL
mGlu4 GRM4 Human Metabotropic glutamate C pEC50 4.41 4.41 4.41 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pEC50 4.64 4.64 4.64 ChEMBL
mGlu3 GRM3 Rat Metabotropic glutamate C pEC50 5.1 5.1 5.1 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pEC50 4.3 4.59 4.82 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pEC50 5.11 5.42 5.7 ChEMBL
mGlu1 GRM1 Rat Metabotropic glutamate C pEC50 4.3 4.54 4.82 ChEMBL
mGlu4 GRM4 Rat Metabotropic glutamate C pEC50 4.41 4.41 4.41 ChEMBL