Taladegib


SMILES Fc1ccc(c(c1)C(F)(F)F)C(=O)N(C1CCN(CC1)c1nnc(c2c1cccc2)c1ccnn1C)C
InChIKey SZBGQDXLNMELTB-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 512.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Bioactivity

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
SMO SMO Human Frizzled F pIC50 8.2 8.2 8.2 Guide to Pharmacology
SMO SMO Mouse Frizzled F pIC50 8.62 8.62 8.62 ChEMBL
SMO SMO Human Frizzled F pIC50 8.38 8.38 8.38 ChEMBL