Alprenolol

Chemical Properties

SMILES C=CCc1ccccc1OCC(CNC(C)C)O
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 8
Molecular weight 249.2

Drug Properties

Type Small molecule
Endogenous No
Approved Yes
InChIKey PAZJSJFMUHDSTF-UHFFFAOYSA-N

Database Connections

External Links
Ligand site mutations α1A β2 5-HT1A 5-HT1B


Bioactivity

Receptor Experimental Data Source
GTP Uniprot Species Family Class Type Min Avg Max Database
β2 ADRB2 Human Adrenoceptors A pKi 9.0 9.0 9.0 Guide to Pharmacology
β2 ADRB2 Bovine Adrenoceptors A pIC50 8.53 8.53 8.53 ChEMBL
β1 ADRB1 Human Adrenoceptors A pIC50 7.86 8.09 8.31 ChEMBL
β1 ADRB1 Human Adrenoceptors A pKd 6.75 7.69 8.37 ChEMBL
β1 ADRB1 Human Adrenoceptors A pKi 8.55 8.55 8.55 ChEMBL
β3 ADRB3 Human Adrenoceptors A pKd 6.86 6.99 7.12 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKd 8.84 9.12 9.53 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKi 8.92 9.04 9.3 ChEMBL
β2 ADRB2 Human Adrenoceptors A pIC50 8.26 8.56 8.94 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.93 6.93 6.93 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.67 7.67 7.67 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pIC50 6.2 6.2 6.2 ChEMBL
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 4.03 4.33 4.63 PDSP KiDatabase
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 4.29 4.29 4.29 PDSP KiDatabase
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.7 6.7 6.7 PDSP KiDatabase
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 6.0 6.08 6.15 PDSP KiDatabase
5-HT2C A0A4X1VZZ6 Pig 5-Hydroxytryptamine A pKi 4.35 4.35 4.35 PDSP KiDatabase
β2 ADRB2 Dog Adrenoceptors A pKi 5.77 6.71 7.64 PDSP KiDatabase
β1 ADRB1 Rat Adrenoceptors A pKi 7.38 7.67 7.96 PDSP KiDatabase
β2 ADRB2 Rat Adrenoceptors A pKi 8.24 8.27 8.3 PDSP KiDatabase
D2 DRD2 Rat Dopamine A pKi 4.0 4.05 4.16 PDSP KiDatabase
β1 ADRB1 Human Adrenoceptors A pKi 7.24 7.24 7.24 PDSP KiDatabase
β2 ADRB2 Human Adrenoceptors A pKi 7.92 7.92 7.92 PDSP KiDatabase
β3 ADRB3 Human Adrenoceptors A pKi 6.46 6.46 6.46 PDSP KiDatabase