thioridazine
| SMILES | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 |
| InChIKey | KLBQZWRITKRQQV-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 4 |
| Hydrogen bond donors | 0 |
| Rotatable bonds | 4 |
| Molecular weight (Da) | 370.2 |
Drug properties
| Molecular type | Small molecule |
| Endogenous/Surrogate | Surrogate |
| Approved drug | Yes |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 7.1 | 7.1 | 7.1 | Guide to Pharmacology |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 7.4 | 7.7 | 8.0 | Guide to Pharmacology |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 7.2 | 7.2 | 7.2 | Guide to Pharmacology |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 7.1 | 7.1 | 7.1 | Guide to Pharmacology |
| D1 | DRD1 | Human | Dopamine | A | pKi | 7.0 | 7.0 | 7.0 | Guide to Pharmacology |
| D5 | DRD5 | Human | Dopamine | A | pKi | 5.6 | 5.6 | 5.6 | Guide to Pharmacology |
| H1 | HRH1 | Human | Histamine | A | pKi | 7.7 | 7.7 | 7.7 | Guide to Pharmacology |
| 5-HT6 | 5HT6R | Rat | 5-Hydroxytryptamine | A | pKi | 8.2 | 8.2 | 8.2 | Guide to Pharmacology |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 8.59 | 8.59 | 8.59 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 6.76 | 6.76 | 6.76 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 8.69 | 8.69 | 8.69 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 7.6 | 7.6 | 7.6 | ChEMBL |
| H2 | HRH2 | Human | Histamine | A | pKi | 6.03 | 6.03 | 6.03 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 7.3 | 7.3 | 7.3 | ChEMBL |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.54 | 8.54 | 8.54 | ChEMBL |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 8.18 | 8.18 | 8.18 | ChEMBL |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 6.74 | 6.95 | 7.16 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pKi | 8.07 | 8.07 | 8.07 | ChEMBL |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 7.96 | 7.96 | 7.96 | ChEMBL |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 7.72 | 7.72 | 7.72 | ChEMBL |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 7.09 | 7.09 | 7.09 | ChEMBL |
| D1 | DRD1 | Human | Dopamine | A | pKi | 7.01 | 7.01 | 7.01 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 7.42 | 7.42 | 7.42 | ChEMBL |
| D4 | DRD4 | Human | Dopamine | A | pKi | 6.29 | 6.29 | 6.29 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 7.47 | 7.47 | 7.47 | ChEMBL |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 7.15 | 7.32 | 7.48 | ChEMBL |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 8.77 | 8.77 | 8.77 | ChEMBL |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 7.64 | 7.64 | 7.64 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 7.08 | 7.99 | 8.9 | ChEMBL |
| D3 | DRD3 | Human | Dopamine | A | pKi | 8.47 | 8.47 | 8.47 | ChEMBL |
| κ | OPRK | Human | Opioid | A | pKi | 6.0 | 6.0 | 6.0 | ChEMBL |
| D2 | DRD2 | Human | Dopamine | A | pKi | 7.57 | 7.86 | 8.1 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 7.22 | 7.93 | 8.96 | PDSP Ki database |
| 5-HT6 | 5HT6R | Rat | 5-Hydroxytryptamine | A | pKi | 8.18 | 8.19 | 8.2 | PDSP Ki database |
| 5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 7.15 | 7.18 | 7.2 | PDSP Ki database |
| D4 | DRD4 | Rat | Dopamine | A | pKi | 7.92 | 8.11 | 8.41 | PDSP Ki database |
| D2 | DRD2 | Rat | Dopamine | A | pKi | 7.17 | 8.15 | 9.0 | PDSP Ki database |
| 5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 7.07 | 7.15 | 7.28 | PDSP Ki database |
| α2C | ADA2C | Rat | Adrenoceptors | A | pKi | 6.26 | 6.26 | 6.26 | PDSP Ki database |
| α2B | ADA2B | Rat | Adrenoceptors | A | pKi | 6.59 | 6.59 | 6.59 | PDSP Ki database |
| D2 | DRD2 | Human | Dopamine | A | pKi | 7.57 | 8.31 | 9.4 | PDSP Ki database |
| D4 | DRD4 | Human | Dopamine | A | pKi | 7.59 | 8.21 | 8.82 | PDSP Ki database |
| H1 | HRH1 | Human | Histamine | A | pKi | 7.66 | 7.76 | 7.85 | PDSP Ki database |
| H1 | HRH1 | Rat | Histamine | A | pKi | 6.92 | 7.44 | 7.7 | PDSP Ki database |
| D1 | DRD1 | Rat | Dopamine | A | pKi | 7.23 | 7.46 | 7.68 | PDSP Ki database |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 7.22 | 7.28 | 7.34 | PDSP Ki database |
| D1 | DRD1 | Bovine | Dopamine | A | pKi | 5.74 | 6.02 | 7.12 | PDSP Ki database |
| D2 | DRD2 | Bovine | Dopamine | A | pKi | 7.8 | 7.83 | 7.85 | PDSP Ki database |
| D5 | DRD5 | Human | Dopamine | A | pKi | 6.52 | 6.59 | 6.67 | PDSP Ki database |
| D1 | DRD1 | Human | Dopamine | A | pKi | 7.0 | 7.03 | 7.05 | PDSP Ki database |
| D3 | DRD3 | Rat | Dopamine | A | pKi | 7.28 | 8.01 | 8.64 | PDSP Ki database |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 7.37 | 7.6 | 7.82 | PDSP Ki database |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 7.48 | 8.2 | 8.57 | PDSP Ki database |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 6.08 | 7.34 | 7.85 | PDSP Ki database |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 6.04 | 7.38 | 8.05 | PDSP Ki database |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 7.89 | 7.9 | 7.92 | PDSP Ki database |
| α1A | F6PTQ1 | Pig | Adrenoceptors | A | pKi | 6.4 | 7.37 | 7.9 | PDSP Ki database |
| α1B | A0A4X1U0M4 | Pig | Adrenoceptors | A | pKi | 7.8 | 7.8 | 7.8 | PDSP Ki database |
| β2 | ADRB2 | Rat | Adrenoceptors | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| D3 | DRD3 | Human | Dopamine | A | pKi | 8.13 | 8.59 | 8.82 | PDSP Ki database |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 6.69 | 6.8 | 6.97 | PDSP Ki database |
| 5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKi | 6.24 | 6.24 | 6.24 | PDSP Ki database |
| 5-HT1E | 5HT1E | Human | 5-Hydroxytryptamine | A | pKi | 6.71 | 6.71 | 6.71 | PDSP Ki database |
| 5-HT5A | 5HT5A | Human | 5-Hydroxytryptamine | A | pKi | 6.44 | 6.44 | 6.44 | PDSP Ki database |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 7.24 | 7.24 | 7.24 | PDSP Ki database |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 7.0 | 7.0 | 7.0 | PDSP Ki database |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.62 | 8.62 | 8.62 | PDSP Ki database |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 6.87 | 6.87 | 6.87 | PDSP Ki database |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 6.47 | 6.47 | 6.47 | PDSP Ki database |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 7.12 | 7.12 | 7.13 | PDSP Ki database |
| β1 | ADRB1 | Human | Adrenoceptors | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| H2 | HRH2 | Human | Histamine | A | pKi | 6.87 | 6.87 | 6.87 | PDSP Ki database |
| EP3 | PE2R3 | Human | Prostanoid | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| EP4 | PE2R4 | Human | Prostanoid | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| CB1 | CNR1 | Rat | Cannabinoid | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.3 | 8.6 | 8.89 | PDSP Ki database |
| M3 | ACM3 | Rat | Acetylcholine (muscarinic) | A | pKi | 7.61 | 7.61 | 7.61 | PDSP Ki database |
| H1 | HRH1 | Guinea pig | Histamine | A | pKi | 7.47 | 7.47 | 7.47 | PDSP Ki database |
| 5-HT1E | 5HT1E | Human | 5-Hydroxytryptamine | A | pKi | 8.17 | 8.17 | 8.17 | Drug Central |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
| 5-HT1B | 5HT1B | Human | 5-Hydroxytryptamine | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| 5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKi | 8.21 | 8.21 | 8.21 | Drug Central |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| 5-HT5A | 5HT5A | Human | 5-Hydroxytryptamine | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 8.07 | 8.07 | 8.07 | Drug Central |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 8.09 | 8.09 | 8.09 | Drug Central |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.06 | 8.06 | 8.06 | Drug Central |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.06 | 8.06 | 8.06 | Drug Central |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
| D4 | DRD4 | Human | Dopamine | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
| D5 | DRD5 | Human | Dopamine | A | pKi | 8.25 | 8.25 | 8.25 | Drug Central |
| H1 | HRH1 | Human | Histamine | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
| H2 | HRH2 | Human | Histamine | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| 5-HT6 | 5HT6R | Rat | 5-Hydroxytryptamine | A | pKi | 8.09 | 8.09 | 8.09 | Drug Central |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 8.07 | 8.07 | 8.07 | Drug Central |
| 5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| 5-HT1B | 5HT1B | Human | 5-Hydroxytryptamine | A | pKi | 6.96 | 6.96 | 6.96 | PDSP Ki database |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 7.2 | 7.25 | 7.3 | Guide to Pharmacology |
| β2 | ADRB2 | Human | Adrenoceptors | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| H4 | HRH4 | Human | Histamine | A | pKi | 5.62 | 5.62 | 5.62 | PDSP Ki database |
| H4 | HRH4 | Human | Histamine | A | pKi | 8.25 | 8.25 | 8.25 | Drug Central |
| κ | OPRK | Human | Opioid | A | pKi | 8.22 | 8.22 | 8.22 | Drug Central |
| α2A | ADA2A | Bovine | Adrenoceptors | A | pKi | 6.34 | 6.34 | 6.34 | PDSP Ki database |
| 5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 7.2 | 7.2 | 7.2 | Guide to Pharmacology |
| H3 | HRH3 | Guinea pig | Histamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| H1 | HRH1 | Rat | Histamine | A | pIC50 | 7.0 | 7.0 | 7.0 | ChEMBL |
| D1 | DRD1 | Rat | Dopamine | A | pIC50 | 5.89 | 6.92 | 7.76 | ChEMBL |
| α1B | ADA1B | Rat | Adrenoceptors | A | pIC50 | 8.33 | 8.33 | 8.33 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pIC50 | 6.42 | 6.42 | 6.42 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pIC50 | 8.29 | 8.29 | 8.29 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pIC50 | 6.77 | 6.77 | 6.77 | ChEMBL |
| H2 | HRH2 | Human | Histamine | A | pIC50 | 6.02 | 6.02 | 6.02 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pIC50 | 6.88 | 6.88 | 6.88 | ChEMBL |
| α1D | ADA1D | Human | Adrenoceptors | A | pIC50 | 8.23 | 8.23 | 8.23 | ChEMBL |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pIC50 | 8.03 | 8.03 | 8.03 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pIC50 | 7.14 | 7.14 | 7.14 | ChEMBL |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pIC50 | 7.1 | 7.1 | 7.1 | ChEMBL |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pIC50 | 7.05 | 7.05 | 7.05 | ChEMBL |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pIC50 | 6.89 | 6.89 | 6.89 | ChEMBL |
| D1 | DRD1 | Human | Dopamine | A | pIC50 | 6.71 | 6.71 | 6.71 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pIC50 | 6.97 | 6.97 | 6.97 | ChEMBL |
| D4 | DRD4 | Human | Dopamine | A | pIC50 | 5.83 | 5.83 | 5.83 | ChEMBL |
| D2 | DRD2 | Rat | Dopamine | A | pIC50 | 7.22 | 7.85 | 8.55 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pIC50 | 7.22 | 7.22 | 7.22 | ChEMBL |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pIC50 | 7.15 | 7.15 | 7.15 | ChEMBL |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pIC50 | 8.15 | 8.15 | 8.15 | ChEMBL |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pIC50 | 7.36 | 7.36 | 7.36 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pIC50 | 8.36 | 8.36 | 8.36 | ChEMBL |
| D3 | DRD3 | Human | Dopamine | A | pIC50 | 8.01 | 8.01 | 8.01 | ChEMBL |
| κ | OPRK | Human | Opioid | A | pIC50 | 5.6 | 5.6 | 5.6 | ChEMBL |
| D2 | DRD2 | Human | Dopamine | A | pIC50 | 7.46 | 7.46 | 7.46 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pEC50 | 8.1 | 8.1 | 8.1 | Drug Central |
| α1A | ADA1A | Human | Adrenoceptors | A | pIC50 | 8.1 | 8.1 | 8.1 | Drug Central |
| D1 | DRD1 | Human | Dopamine | A | pIC50 | 8.15 | 8.15 | 8.15 | Drug Central |
| D2 | DRD2 | Human | Dopamine | A | pIC50 | 8.13 | 8.13 | 8.13 | Drug Central |
| D3 | DRD3 | Human | Dopamine | A | pIC50 | 8.14 | 8.14 | 8.14 | Drug Central |
| α1A | ADA1A | Rat | Adrenoceptors | A | pIC50 | 8.08 | 8.08 | 8.08 | Drug Central |
| H1 | HRH1 | Rat | Histamine | A | pIC50 | 8.15 | 8.15 | 8.15 | Drug Central |
| D1 | DRD1 | Rat | Dopamine | A | pIC50 | 8.11 | 8.11 | 8.11 | Drug Central |
| D2 | DRD2 | Rat | Dopamine | A | pIC50 | 8.07 | 8.07 | 8.07 | Drug Central |
| NPS | NPSR1 | Human | Neuropeptide S | A | Potency | 4.9 | 4.9 | 4.9 | ChEMBL |