Tiotropium


SMILES O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3
InChIKey LERNTVKEWCAPOY-FPISHFTHSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 392.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Bioactivity

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M2 ACM2 Human Acetylcholine (muscarinic) A pKd 10.3 10.3 10.3 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 9.9 10.3 10.7 Guide to Pharmacology
M3 ACM3 Human Acetylcholine (muscarinic) A pKd 10.7 10.7 10.7 Guide to Pharmacology
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 9.5 10.3 11.1 Guide to Pharmacology
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 9.6 10.15 10.7 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 10.2 10.4 10.6 Guide to Pharmacology
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 9.8 10.0 10.2 Guide to Pharmacology
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.96 6.96 6.96 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.96 6.96 6.96 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 6.95 6.95 6.95 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.96 6.96 6.96 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.96 6.96 6.96 Drug Central
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 7.01 7.01 7.01 Drug Central
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 7.01 7.01 7.01 Drug Central
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 7.02 7.02 7.02 Drug Central