tapentadol


SMILES CC[C@@H](c1cccc(c1)O)[C@H](CN(C)C)C
InChIKey KWTWDQCKEHXFFR-SMDDNHRTSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 221.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Human Opioid A pKi 6.8 6.8 6.8 Guide to Pharmacology
μ OPRM Human Opioid A pKi 6.8 6.8 6.8 ChEMBL
μ OPRM Human Opioid A pKi 8.15 8.15 8.15 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Human Opioid A pEC50 6.17 6.17 6.17 ChEMBL