vilazodone


SMILES N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2
InChIKey SGEGOXDYSFKCPT-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Molecular weight (Da) 441.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 9.7 9.7 9.7 Guide to Pharmacology
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.41 5.41 5.41 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.01 9.08 9.7 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.01 8.01 8.01 Drug Central
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.27 8.27 8.27 Drug Central
D2 DRD2 Human Dopamine A pKi 6.18 6.18 6.18 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pIC50 9.52 9.52 9.52 Guide to Pharmacology
5-HT4 5HT4R Human 5-Hydroxytryptamine A pIC50 6.6 6.6 6.6 Guide to Pharmacology
D2 DRD2 Human Dopamine A pIC50 6.18 6.18 6.18 Guide to Pharmacology
D3 DRD3 Human Dopamine A pIC50 7.15 7.15 7.15 Guide to Pharmacology
H1 HRH1 Human Histamine A pIC50 6.5 6.5 6.5 Guide to Pharmacology
5-HT1D 5HT1D Rat 5-Hydroxytryptamine A pIC50 5.4 5.4 5.4 ChEMBL
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pIC50 5.52 5.52 5.52 ChEMBL
D4 DRD4 Rat Dopamine A pIC50 5.47 5.47 5.47 ChEMBL
5-HT4 5HT4R Rat 5-Hydroxytryptamine A pIC50 6.6 6.6 6.6 ChEMBL
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pIC50 5.52 5.52 5.52 ChEMBL
D3 DRD3 Rat Dopamine A pIC50 7.15 7.15 7.15 ChEMBL
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pIC50 5.7 5.7 5.7 ChEMBL
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pIC50 5.3 5.3 5.3 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 6.18 6.18 6.18 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pEC50 9.92 9.92 9.92 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pIC50 9.7 9.83 9.96 ChEMBL
5-HT4 5HT4R Human 5-Hydroxytryptamine A pIC50 8.18 8.18 8.18 Drug Central
D2 DRD2 Human Dopamine A pIC50 8.21 8.21 8.21 Drug Central
D3 DRD3 Human Dopamine A pIC50 8.15 8.15 8.15 Drug Central
H1 HRH1 Human Histamine A pIC50 8.19 8.19 8.19 Drug Central
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pIC50 8.28 8.28 8.28 Drug Central
D2 DRD2 Rat Dopamine A pIC50 8.21 8.21 8.21 Drug Central
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pIC50 8.26 8.26 8.26 Drug Central
D3 DRD3 Rat Dopamine A pIC50 8.15 8.15 8.15 Drug Central
5-HT4 5HT4R Rat 5-Hydroxytryptamine A pIC50 8.18 8.18 8.18 Drug Central
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pIC50 8.24 8.24 8.24 Drug Central
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 8.02 8.02 8.02 Drug Central
5-HT1D 5HT1D Rat 5-Hydroxytryptamine A pIC50 8.27 8.27 8.27 Drug Central
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pIC50 8.26 8.26 8.26 Drug Central
D4 DRD4 Rat Dopamine A pIC50 8.26 8.26 8.26 Drug Central
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 9.52 9.52 9.52 ChEMBL