substance P


SMILES None
InChIKey ADNPLDHMAVUMIW-CUZNLEPHSA-N
Sequence RPKPQQFFGLM

Chemical properties

Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight (Da)

Drug properties

Molecular type Peptide
Endogenous/Surrogate Endogenous
Approved drug No

Database connections

Structure pdb 7RMI 7RMH 7P02 7VDM 7P00 7RMG

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Guinea pig Histamine A pKd 9.9 9.9 9.9 ChEMBL
H1 HRH1 Guinea pig Histamine A pKi 8.78 8.78 8.78 ChEMBL
H1 HRH1 Human Histamine A pKi 8.8 8.8 8.8 ChEMBL
H1 HRH1 Human Histamine A pKi 5.0 8.39 9.34 PDSP Ki database
H1 HRH1 Human Histamine A pKi 8.0 8.0 8.0 Drug Central
H1 HRH1 Human Histamine A pKi 8.5 8.75 9.0 Guide to Pharmacology
H1 HRH1 Guinea pig Histamine A pKd 8.0 8.0 8.0 Drug Central
H1 HRH1 Guinea pig Histamine A pKi 8.94 9.15 9.51 PDSP Ki database
H1 HRH1 Rat Histamine A pKi 8.25 8.25 8.25 PDSP Ki database
H1 HRH1 Mouse Histamine A pKi 8.04 8.04 8.04 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NPS NPSR1 Human Neuropeptide S A Potency 7.3 7.3 7.3 ChEMBL