ambrisentan


SMILES COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1
InChIKey OUJTZYPIHDYQMC-LJQANCHMSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 378.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
LPA3 LPAR3 Human Lysophospholipid (LPA) A pKi 5.77 5.77 5.77 ChEMBL
LPA1 LPAR1 Human Lysophospholipid (LPA) A pKi 7.75 7.75 7.75 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
LPA1 LPAR1 Human Lysophospholipid (LPA) A pIC50 6.0 6.0 6.0 ChEMBL
LPA3 LPAR3 Human Lysophospholipid (LPA) A pIC50 6.76 6.76 6.76 Guide to Pharmacology
LPA1 LPAR1 Mouse Lysophospholipid (LPA) A pIC50 6.96 6.96 6.96 Guide to Pharmacology