GPCRdb

vilazodone

Agent/drug
Bioactivity

vilazodone

SMILES	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5oc(C(N)=O)cc5c4)CC3)c2c1
InChIKey	SGEGOXDYSFKCPT-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	2
Rotatable bonds	7
Molecular weight (Da)	441.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	8FYL

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	6.56	6.56	6.56	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.54	5.54	5.54	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.14	6.14	6.14	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.60	5.60	5.60	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.86	5.86	5.86	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.60	5.60	5.60	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	6.14	6.14	6.14	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	9.70	9.70	9.70	Guide to Pharmacology
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.50	8.46	9.70	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.01	8.01	8.01	Drug Central
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.91	5.91	5.91	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	6.43	6.43	6.43	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.19	7.19	7.19	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	6.02	6.02	6.02	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	5.41	5.75	6.10	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	8.27	8.27	8.27	Drug Central
D₂	DRD2	Human	Dopamine	A	pKi	6.18	6.22	6.26	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	6.88	6.88	6.88	ChEMBL
D₄	DRD4	Human	Dopamine	A	pKi	6.08	6.08	6.08	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	6.44	6.44	6.44	ChEMBL

Showing 1 to 20 of 20 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pIC50	9.52	9.52	9.52	Guide to Pharmacology
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pIC50	9.70	9.83	9.96	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pEC50	9.10	9.65	9.92	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	8.02	8.02	8.02	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	9.52	9.52	9.52	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	5.30	5.30	5.30	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	8.28	8.28	8.28	Drug Central
5-HT_1D	5HT1D	Rat	5-Hydroxytryptamine	A	pIC50	5.40	5.40	5.40	ChEMBL
5-HT_1D	5HT1D	Rat	5-Hydroxytryptamine	A	pIC50	8.27	8.27	8.27	Drug Central
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pIC50	5.70	5.70	5.70	ChEMBL
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pIC50	8.24	8.24	8.24	Drug Central
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pIC50	6.60	6.60	6.60	Guide to Pharmacology
5-HT₄	5HT4R	Rat	5-Hydroxytryptamine	A	pIC50	6.60	6.60	6.60	ChEMBL
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pIC50	8.18	8.18	8.18	Drug Central
5-HT₄	5HT4R	Rat	5-Hydroxytryptamine	A	pIC50	8.18	8.18	8.18	Drug Central
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pIC50	5.52	5.52	5.52	ChEMBL
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pIC50	8.26	8.26	8.26	Drug Central
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pIC50	5.52	5.52	5.52	ChEMBL
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pIC50	8.26	8.26	8.26	Drug Central
D₂	DRD2	Human	Dopamine	A	pIC50	6.18	6.18	6.18	Guide to Pharmacology

Showing 1 to 20 of 33 entries

vilazodone

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 3

Phase III 2

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	8FYL

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Cannabis dependence, unspecified	6C41.2Z	N06A	0.402	2	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.596	4	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Generalised anxiety disorder	6B00	N06A	0.543	3	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Post traumatic stress disorder	6B40	N06A	0.554	2	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Single episode depressive disorder, severe, without psychotic symptoms	6A70.3	N06A	0.634	3	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Symptoms and signs involving cognition, unspecified	MB21.Z	N06A	0.045	2	Yes

Showing 1 to 6 of 6 entries