GPCRdb

ziprasidone

Agent/drug
Bioactivity

ziprasidone

SMILES	O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1
InChIKey	MVWVFYHBGMAFLY-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	1
Rotatable bonds	4
Molecular weight (Da)	412.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	9.30	9.30	9.30	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.22	8.22	8.22	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.10	8.10	8.10	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	8.03	8.03	8.03	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.05	8.05	8.05	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.09	8.09	8.09	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.74	7.74	7.74	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.80	6.80	6.80	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.20	8.20	8.20	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.32	7.32	7.32	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.11	7.15	7.23	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.15	8.15	8.15	Drug Central
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.00	5.29	5.59	PDSP Ki database
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.25	8.25	8.25	Drug Central
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.00	5.15	5.30	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	8.28	8.28	8.28	Drug Central
δ	OPRD	Mouse	Opioid	A	pKi	6.00	6.00	6.00	PDSP Ki database
κ	OPRK	Guinea pig	Opioid	A	pKi	6.00	6.00	6.00	PDSP Ki database
μ	OPRM	Rat	Opioid	A	pKi	6.00	6.00	6.00	PDSP Ki database

Showing 1 to 20 of 107 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pEC50	8.07	8.07	8.07	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	9.38	9.38	9.38	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	8.30	8.30	8.30	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	6.82	6.82	6.82	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	8.17	8.17	8.17	Drug Central

Showing 1 to 5 of 5 entries

ziprasidone

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 10

Phase II 22

Phase III 6

Phase IV 21

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

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Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Autism spectrum disorder, unspecified	2	6A02.Z	N05A	0.451
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Bipolar type I disorder, unspecified	4	6A60.Z	N05A	0.591
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Depressive disorders, unspecified	3	6A7Z	N05A	0.596
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Opioid dependence, unspecified	1	6C43.2Z	N05A	0.370
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Personality disorder, severity unspecified	2	6D10.Z	N05A	0.113
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizoaffective disorder, unspecified	4	6A21.Z	N05A	0.590
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizophrenia or other primary psychotic disorders, unspecified	4	6A2Z	N05A	0.566
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizophrenia, episode unspecified	4	6A20.Z	N05A	0.622
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Single episode depressive disorder, severe, without psychotic symptoms	2	6A70.3	N05A	0.634
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Social anxiety disorder	2	6B04	N05A	0.373
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Unknown or unspecified psychoactive substance dependence, substance and state of remission unspecified	1	6C4G.2Z	N05A	0.003
5HT1D	5-HT_1D receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Bipolar type I disorder, unspecified	4	6A60.Z	N05A	0.074
5HT1D	5-HT_1D receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Depressive disorders, unspecified	3	6A7Z	N05A	0.408
5HT1D	5-HT_1D receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizoaffective disorder, unspecified	4	6A21.Z	N05A	0.503
5HT1D	5-HT_1D receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizophrenia or other primary psychotic disorders, unspecified	4	6A2Z	N05A	0.370
5HT1D	5-HT_1D receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizophrenia, episode unspecified	4	6A20.Z	N05A	0.591
5HT1D	5-HT_1D receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Single episode depressive disorder, severe, without psychotic symptoms	2	6A70.3	N05A	0.091
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Autism spectrum disorder, unspecified	2	6A02.Z	N05A	0.462
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Bipolar type I disorder, unspecified	4	6A60.Z	N05A	0.609
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Depressive disorders, unspecified	3	6A7Z	N05A	0.607

Showing 1 to 20 of 50 entries

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Main reference

ziprasidone

ziprasidone

Chemical Properties

Database connections

Bioactivities

ziprasidone

Drug properties

Distribution across phases (no. indications)

Database connections

Sankey plot

Drug Information