GPCRdb

MECLIZINE

Agent/drug
Bioactivity

MECLIZINE

SMILES	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1
InChIKey	OCJYIGYOJCODJL-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	0
Rotatable bonds	5
Molecular weight (Da)	390.2

Database connections

ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb
Ligand site mutations	H₁

No bioactivity data available.

MECLIZINE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 1

Phase II 1

Phase III 0

Phase IV 5

Database connections

ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb
Ligand site mutations	H₁

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Hepatocellular carcinoma of liver	1	2C12.02		0.041
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Motion sickness	4	NF08.3		0.598
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Nausea	4	MD90.0		0.592
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Nausea or vomiting	4	MD90		0.526
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Nicotine dependence, unspecified	2	6C4A.2Z		0.074
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Vertigo, unspecified	4	MB48.0Z		0.577
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Vomiting	4	MD90.1		0.588

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