GPCRdb

azelastine

Agent/drug
Bioactivity

azelastine

SMILES	CN1CCCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)CC1
InChIKey	MBUVEWMHONZEQD-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	0
Rotatable bonds	3
Molecular weight (Da)	381.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	6.30	7.10	7.30	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.30	7.30	7.30	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.44	6.93	7.30	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.48	6.48	6.48	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.84	5.84	5.84	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.64	6.64	6.64	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.37	5.37	5.37	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	6.05	6.05	6.05	ChEMBL
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	5.27	5.27	5.27	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.64	6.64	6.64	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.70	7.70	7.70	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.11	8.11	8.11	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.30	6.30	6.30	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.20	8.20	8.20	Drug Central
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	5.68	5.68	5.68	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	6.41	6.41	6.41	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	6.24	6.24	6.24	ChEMBL

Showing 1 to 20 of 29 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	5.20	5.20	5.20	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	8.28	8.28	8.28	Drug Central

Showing 1 to 2 of 2 entries

azelastine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic conjunctivitis	9A60.02	R06A, S01G, R01A	0.589	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic or hypersensitivity conditions of unspecified type	4A8Z	R06A, S01G, R01A	0.494	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis due to other seasonal allergens	CA08.01	R06A, S01G, R01A	0.610	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis, unspecified	CA08.0Z	R06A, S01G, R01A	0.616	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Nasal congestion	MD11.9	R06A, S01G, R01A	0.607	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Non-allergic rhinitis, unspecified	CA08.1Z	R06A, S01G, R01A	0.324	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Other allergic rhinitis	CA08.03	R06A, S01G, R01A	0.602	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Vasomotor rhinitis	CA08.3	R06A, S01G, R01A	0.590	4	Yes

Showing 1 to 8 of 8 entries