Chembl1644183


SMILES O=C(O)CCNC(=O)c1ccc(Cn2nc(-c3cc(Cl)cc(Cl)c3)cc2-c2ccc(OC(F)(F)F)cc2)cc1
InChIKey IGCXZPHCSPIQHB-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 9
Molecular weight (Da) 577.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections


Bioactivity

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
glucagon E2R517 Dog Glucagon B1 pIC50 6.4 6.4 6.4 ChEMBL
glucagon GLR Mouse Glucagon B1 pIC50 5.7 5.7 5.7 ChEMBL
GIP GIPR Human Glucagon B1 pIC50 5.12 5.16 5.2 ChEMBL
glucagon GLR Rat Glucagon B1 pIC50 5.58 5.58 5.58 ChEMBL
glucagon GLR Human Glucagon B1 pIC50 6.94 7.11 7.36 ChEMBL