Bremelanotide

Chemical Properties

SMILES CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C
Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight

Drug Properties

Type Peptide
Endogenous No
Approved Yes
InChIKey FFHBJDQSGDNCIV-MFVUMRCOSA-N

Database Connections

External Links
Structure pdb 7F55


Bioactivity

Receptor Experimental Data Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MC1 MSHR Human Melanocortin A pKi 8.19 8.19 8.19 Guide to Pharmacology
MC3 MC3R Human Melanocortin A pKi 7.28 7.28 7.28 Guide to Pharmacology
MC4 MC4R Human Melanocortin A pKi 9.6 9.6 9.6 Guide to Pharmacology
MC5 MC5R Human Melanocortin A pKi 7.77 7.77 7.77 Guide to Pharmacology
MC1 MSHR Human Melanocortin A pKi 8.19 8.46 8.72 ChEMBL
MC1 MSHR Human Melanocortin A pEC50 10.02 10.02 10.02 ChEMBL
MC5 MC5R Human Melanocortin A pKi 7.77 7.77 7.77 ChEMBL
MC5 MC5R Human Melanocortin A pIC50 6.71 6.71 6.71 ChEMBL
MC3 MC3R Human Melanocortin A pKi 6.72 7.0 7.28 ChEMBL
MC3 MC3R Human Melanocortin A pEC50 8.62 8.62 8.62 ChEMBL
MC4 MC4R Human Melanocortin A pKi 7.61 8.61 9.6 ChEMBL
MC4 MC4R Human Melanocortin A pEC50 8.39 9.23 9.7 ChEMBL