compound 11s [PMID: 19433355]


SMILES C#CCNc1ccnc2c1c1ncn(c(=O)c1s2)c1ccc(cc1)OC
InChIKey WIAAIYJUCDAKFY-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 362.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 8.33 8.33 8.33 Guide to Pharmacology
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 8.46 8.46 8.46 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Human Metabotropic glutamate C pIC50 8.68 8.68 8.68 Guide to Pharmacology
mGlu1 GRM1 Human Metabotropic glutamate C pIC50 8.17 8.43 8.68 ChEMBL