GPCRdb

cannabidiol

Agent/drug
Bioactivity

cannabidiol

SMILES	C=C(C)[C@@H]1CCC(C)=C[C@H]1c1c(O)cc(CCCCC)cc1O
InChIKey	QHMBSVQNZZTUGM-ZWKOTPCHSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	2
Rotatable bonds	6
Molecular weight (Da)	314.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.50	5.50	5.50	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.43	5.43	5.43	ChEMBL
δ	OPRD	Human	Opioid	A	pKi	5.19	5.19	5.19	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	5.64	5.64	5.64	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	5.89	5.89	5.89	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.96	5.96	5.96	ChEMBL
CB₁	CNR1	Human	Cannabinoid	A	pKi	5.36	5.55	5.84	ChEMBL
CB₁	CNR1	Rat	Cannabinoid	A	pKi	5.36	5.36	5.36	PDSP Ki database
CB₁	CNR1	Human	Cannabinoid	A	pKi	8.25	8.25	8.25	Drug Central
CB₁	CNR1	Rat	Cannabinoid	A	pKi	8.23	8.23	8.23	Drug Central
CB₂	CNR2	Human	Cannabinoid	A	pKi	5.00	5.63	6.43	ChEMBL
CB₂	CNR2	Human	Cannabinoid	A	pKi	8.26	8.26	8.26	Drug Central
CB₂	CNR2	Mouse	Cannabinoid	A	pKi	8.18	8.18	8.18	Drug Central
CB₂	CNR2	Mouse	Cannabinoid	A	pKi	6.64	6.64	6.64	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	5.57	5.57	5.57	ChEMBL
H₃	HRH3	Human	Histamine	A	pKi	5.51	5.51	5.51	ChEMBL

Showing 1 to 16 of 16 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

μ	OPRM	Human	Opioid	A	pIC50	5.75	6.13	6.51	ChEMBL
μ	OPRM	Human	Opioid	A	pEC50	4.38	4.38	4.38	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pEC50	5.10	5.10	5.10	ChEMBL
CB₂	CNR2	Human	Cannabinoid	A	pEC50	6.20	7.25	8.10	ChEMBL
GPR18	GPR18	Human	GPR18, GPR55 and GPR119	A	pEC50	4.29	4.29	4.29	Guide to Pharmacology
GPR18	GPR18	Human	GPR18, GPR55 and GPR119	A	pEC50	8.37	8.37	8.37	Drug Central
GPR55	GPR55	Human	GPR18, GPR55 and GPR119	A	pIC50	6.35	6.40	6.46	Guide to Pharmacology
GPR55	GPR55	Human	GPR18, GPR55 and GPR119	A	pEC50	8.20	8.20	8.20	Drug Central
GPR55	GPR55	Human	GPR18, GPR55 and GPR119	A	pEC50	6.35	6.35	6.35	ChEMBL

Showing 1 to 9 of 9 entries

cannabidiol

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 7

Phase II 30

Phase III 8

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Acute graft-versus-host disease	4B24.0	N03A	0.074	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Alcohol dependence, unspecified	6C40.2Z	N03A	0.105	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Amyotrophic lateral sclerosis	8B60.0	N03A	0.285	3	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Anorexia Nervosa, unspecified	6B80.Z	N03A	0.266	1	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Anxiety	MB24.3	N03A	0.121	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Autism spectrum disorder, unspecified	6A02.Z	N03A	0.092	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Autoimmune hepatitis	DB96.0	N03A	0.074	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	N03A	0.295	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	COVID-19	RA01	N03A	0.100	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Cannabis dependence, unspecified	6C41.2Z	N03A	0.125	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Chronic pain, unspecified	MG30.Z	N03A	0.483	3	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Chronic widespread pain	MG30.01	N03A	0.290	3	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Cocaine dependence, unspecified	6C45.2Z	N03A	0.078	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Crohn disease, unspecified site	DD70.Z	N03A	0.084	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Disorders due to use of opioids, unspecified	6C43.Z	N03A	0.111	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Essential hypertension, unspecified	BA00.Z	N03A	0.040	1	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Essential tremor or related tremors	8A04.1	N03A	0.046	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Fragile X chromosome	LD55	N03A	0.286	3	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Graft-versus-host disease, unspecified	4B24.Z	N03A	0.099	2	Yes
CNR1	CB₁ receptor	Cannabinoid receptors	Lipid receptors	Class A	Heart failure, unspecified	BD1Z	N03A	0.039	1	Yes

Showing 1 to 20 of 48 entries

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cannabidiol

cannabidiol

Chemical Properties

Database connections

Bioactivities

cannabidiol

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information