dextromethorphan


SMILES COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C
InChIKey MKXZASYAUGDDCJ-NJAFHUGGSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 1
Molecular weight (Da) 271.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Rat Opioid A pKi 5.0 5.0 5.0 PDSP Ki database
κ OPRK Rat Opioid A pKi 5.15 5.15 5.15 PDSP Ki database
μ OPRM Rat Opioid A pKi 5.89 5.89 5.89 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.75 5.08 5.4 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 8.2 8.2 8.2 ChEMBL
TAS2R46 T2R46 Human Taste 2 T2 pEC50 8.35 8.35 8.35 Drug Central
TAS2R46 T2R46 Human Taste 2 T2 pEC50 4.51 4.51 4.51 ChEMBL