BIFEPRUNOX


SMILES O=c1[nH]c2cccc(N3CCN(Cc4cccc(-c5ccccc5)c4)CC3)c2o1
InChIKey CYGODHVAJQTCBG-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 385.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Rat Dopamine A pKi 8.81 8.81 8.81 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.19 7.19 7.19 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.03 8.03 8.03 ChEMBL
D2 DRD2 Human Dopamine A pKi 8.64 9.17 10.4 ChEMBL
D2 DRD2 Human Dopamine A pKi 10.0 10.2 10.4 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pEC50 6.49 6.49 6.49 ChEMBL
D2 DRD2 Human Dopamine A pIC50 8.54 8.54 8.54 ChEMBL