fasiglifam


SMILES OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C
InChIKey BZCALJIHZVNMGJ-HSZRJFAPSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 11
Molecular weight (Da) 524.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 4PHU 8EJC 8EJK

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
FFA1 FFAR1 Rat Free fatty acid A pKi 6.85 6.85 6.85 ChEMBL
FFA1 FFAR1 Human Free fatty acid A pKi 7.42 7.62 8.11 ChEMBL
FFA1 FFAR1 Human Free fatty acid A pKd 7.92 8.13 8.35 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
FFA1 FFAR1 Human Free fatty acid A pEC50 7.1 7.1 7.1 Guide to Pharmacology
FFA1 FFAR1 Mouse Free fatty acid A pEC50 8.07 8.07 8.07 ChEMBL
FFA1 FFAR1 Rat Free fatty acid A pEC50 4.57 6.61 7.44 ChEMBL
FFA1 FFAR1 Human Free fatty acid A pEC50 5.29 7.54 9.46 ChEMBL