Chembl231156


SMILES O=C(NC[C@H]1C[C@@H]1CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1
InChIKey KRMPDMJUDCQCAJ-FGZHOGPDSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 494.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections


Bioactivity

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.1 7.1 7.1 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.23 7.23 7.23 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.33 7.33 7.33 ChEMBL
D3 DRD3 Human Dopamine A pKi 9.0 9.0 9.0 ChEMBL
D3 DRD3 Human Dopamine A pIC50 7.84 7.84 7.84 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.27 7.27 7.27 ChEMBL
D2 DRD2 Human Dopamine A pIC50 6.17 6.17 6.17 ChEMBL
D2 DRD2 Human Dopamine A pEC50 6.82 6.82 6.82 ChEMBL