genistein


SMILES Oc1ccc(cc1)c1coc2c(c1=O)c(O)cc(c2)O
InChIKey TZBJGXHYKVUXJN-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 1
Molecular weight (Da) 270.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
A2A AA2AR Rat Adenosine A pKi 4.44 4.44 4.44 ChEMBL
A1 AA1R Rat Adenosine A pKi 5.3 5.3 5.3 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.11 5.11 5.11 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.52 5.52 5.52 ChEMBL
A2A AA2AR Human Adenosine A pKi 5.01 5.01 5.01 ChEMBL
A1 AA1R Human Adenosine A pKi 4.93 4.93 4.93 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
TAS2R14 T2R14 Human Taste 2 T2 pEC50 4.19 4.19 4.19 Guide to Pharmacology
TAS2R39 T2R39 Human Taste 2 T2 pEC50 4.31 4.31 4.31 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 4.83 4.83 4.83 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 4.98 4.98 4.98 ChEMBL
A2A AA2AR Human Adenosine A pIC50 4.76 4.76 4.76 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 6.0 6.0 6.0 ChEMBL
A1 AA1R Human Adenosine A pIC50 4.7 4.7 4.7 ChEMBL