idazoxan
| SMILES | C1CN=C(N1)C2COC3=CC=CC=C3O2 |
| InChIKey | HPMRFMKYPGXPEP-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 4 |
| Hydrogen bond donors | 1 |
| Rotatable bonds | 1 |
| Molecular weight (Da) | 204.1 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | No |
Database connections
| Ligand site mutations | α2A |
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 7.2 | 7.2 | 7.2 | Guide to Pharmacology |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 6.4 | 6.4 | 6.4 | Guide to Pharmacology |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 7.2 | 7.2 | 7.2 | Guide to Pharmacology |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 7.0 | 7.43 | 7.64 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 7.72 | 7.74 | 7.75 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 8.1 | 8.13 | 8.15 | ChEMBL |
| 5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| 5-HT2A | 5HT2A | Rat | 5-Hydroxytryptamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| D1 | DRD1 | Human | Dopamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| D2 | DRD2 | Human | Dopamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 6.18 | 6.18 | 6.18 | PDSP Ki database |
| 5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 7.7 | 8.22 | 9.25 | PDSP Ki database |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 8.01 | 8.28 | 8.72 | PDSP Ki database |
| α2B | ADA2B | Rat | Adrenoceptors | A | pKi | 8.33 | 8.33 | 8.33 | PDSP Ki database |
| α2C | ADA2C | North American opossum | Adrenoceptors | A | pKi | 8.62 | 8.62 | 8.62 | PDSP Ki database |
| D2 | DRD2 | Rat | Dopamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| 5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 6.0 | 6.0 | 6.0 | PDSP Ki database |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 7.0 | 7.21 | 7.43 | PDSP Ki database |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 6.79 | 6.81 | 6.84 | PDSP Ki database |
| α2A | ADA2A | Bovine | Adrenoceptors | A | pKi | 8.82 | 8.82 | 8.82 | ChEMBL |
| α1A | ADA1A | Bovine | Adrenoceptors | A | pKi | 6.3 | 6.3 | 6.3 | ChEMBL |
| 5-HT2C | K7GSR7 | Pig | 5-Hydroxytryptamine | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| α2B | ADA2B | Human | Adrenoceptors | A | pIC50 | 7.71 | 7.71 | 7.71 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pIC50 | 7.27 | 7.27 | 7.27 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pIC50 | 8.08 | 8.08 | 8.08 | ChEMBL |
| α1A | ADA1A | Human | Adrenoceptors | A | pIC50 | 5.54 | 5.54 | 5.54 | ChEMBL |
| NPS | NPSR1 | Human | Neuropeptide S | A | Potency | 5.0 | 5.0 | 5.0 | ChEMBL |