[Leu]enkephalin
SMILES | None |
InChIKey | URLZCHNOLZSCCA-UHFFFAOYSA-N |
Sequence | YGGFL |
Chemical properties
Hydrogen bond acceptors | None |
Hydrogen bond donors | None |
Rotatable bonds | None |
Molecular weight (Da) |
Drug properties
Molecular type | Peptide |
Physiological/Surrogate | Endogenous |
Approved drug | No |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
δ | OPRD | Human | Opioid | A | pKi | 8.7 | 8.7 | 8.7 | Guide to Pharmacology |
μ | OPRM | Human | Opioid | A | pKi | 8.1 | 8.1 | 8.1 | Guide to Pharmacology |
δ | OPRD | Mouse | Opioid | A | pKi | 8.4 | 8.4 | 8.4 | Guide to Pharmacology |
κ | OPRK | Rat | Opioid | A | pKi | 6.0 | 6.0 | 6.0 | Guide to Pharmacology |
δ | O57585 | Zebrafish | Opioid | A | pKi | 7.14 | 7.14 | 7.14 | ChEMBL |
δ | OPRD | Mouse | Opioid | A | pKi | 8.16 | 8.18 | 8.2 | ChEMBL |
κ | OPRK | Guinea pig | Opioid | A | pKi | 5.34 | 5.34 | 5.34 | ChEMBL |
μ | OPRM | Rat | Opioid | A | pKi | 7.56 | 8.05 | 8.62 | ChEMBL |
δ | OPRD | Human | Opioid | A | pKi | 7.51 | 8.56 | 9.15 | ChEMBL |
μ | OPRM | Human | Opioid | A | pKi | 5.32 | 7.6 | 8.69 | ChEMBL |
μ | OPRM | Human | Opioid | A | pKi | 8.13 | 8.26 | 8.47 | PDSP Ki database |
δ | OPRD | Human | Opioid | A | pKi | 8.4 | 8.94 | 9.74 | PDSP Ki database |
δ | A0A286XTF2 | Guinea pig | Opioid | A | pKi | 8.8 | 8.8 | 8.8 | PDSP Ki database |
κ | OPRK | Human | Opioid | A | pKi | 5.0 | 5.5 | 6.0 | PDSP Ki database |
κ | OPRK | Guinea pig | Opioid | A | pKi | 5.0 | 5.17 | 5.34 | PDSP Ki database |
μ | OPRM | Mouse | Opioid | A | pKi | 8.04 | 8.11 | 8.18 | PDSP Ki database |
δ | OPRD | Mouse | Opioid | A | pKi | 8.6 | 8.6 | 8.6 | PDSP Ki database |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
δ | OPRD | Mouse | Opioid | A | pIC50 | 7.65 | 8.34 | 8.97 | ChEMBL |
δ | OPRD | Mouse | Opioid | A | pEC50 | 7.13 | 7.13 | 7.13 | ChEMBL |
μ | OPRM | Rat | Opioid | A | pIC50 | 7.3 | 7.3 | 7.3 | ChEMBL |
δ | OPRD | Human | Opioid | A | pEC50 | 6.92 | 8.42 | 10.1 | ChEMBL |
κ | OPRK | Human | Opioid | A | pEC50 | 7.1 | 7.1 | 7.1 | ChEMBL |
μ | OPRM | Human | Opioid | A | pEC50 | 5.89 | 7.07 | 8.89 | ChEMBL |
μ | OPRM | Human | Opioid | A | pIC50 | 5.02 | 5.02 | 5.02 | ChEMBL |
μ | OPRM | Mouse | Opioid | A | pIC50 | 7.7 | 7.81 | 8.03 | ChEMBL |