CHEMBL2207640


SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(C)CC3)c3cccccc2-3)CC1
InChIKey PLYQWXWXIUOYQJ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 6
Molecular weight (Da) 444.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Pig 5-Hydroxytryptamine A pKi 5.68 5.68 5.68 ChEMBL
D1 DRD1 Pig Dopamine A pKi 5.19 5.19 5.19 ChEMBL
H2 HRH2 Human Histamine A pKi 5.26 5.26 5.26 ChEMBL
D4 DRD4 Human Dopamine A pKi 8.42 8.42 8.42 ChEMBL
H3 HRH3 Human Histamine A pKi 5.26 5.26 5.26 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.34 6.34 6.34 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.22 7.23 7.24 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database