sphingosine 1-phosphate
| SMILES | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O |
| InChIKey | DUYSYHSSBDVJSM-KRWOKUGFSA-N |
Chemical properties
| Hydrogen bond acceptors | 4 |
| Hydrogen bond donors | 4 |
| Rotatable bonds | 17 |
| Molecular weight (Da) | 379.2 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Endogenous |
| Approved drug | No |
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| S1P1 | S1PR1 | Human | Lysophospholipid (S1P) | A | pKd | 7.88 | 8.64 | 9.41 | Guide to Pharmacology |
| S1P2 | S1PR2 | Human | Lysophospholipid (S1P) | A | pKd | 7.57 | 7.63 | 7.69 | Guide to Pharmacology |
| S1P3 | S1PR3 | Human | Lysophospholipid (S1P) | A | pKd | 7.58 | 8.61 | 9.64 | Guide to Pharmacology |
| S1P5 | S1PR5 | Rat | Lysophospholipid (S1P) | A | pKd | 8.7 | 8.7 | 8.7 | Guide to Pharmacology |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| S1P1 | S1PR1 | Human | Lysophospholipid (S1P) | A | pEC50 | 7.1 | 8.89 | 9.4 | Guide to Pharmacology |
| S1P2 | S1PR2 | Human | Lysophospholipid (S1P) | A | pEC50 | 8.05 | 8.3 | 8.54 | Guide to Pharmacology |
| S1P3 | S1PR3 | Human | Lysophospholipid (S1P) | A | pEC50 | 8.4 | 9.1 | 9.8 | Guide to Pharmacology |
| S1P4 | S1PR4 | Human | Lysophospholipid (S1P) | A | pIC50 | 6.1 | 6.55 | 7.0 | Guide to Pharmacology |
| S1P4 | S1PR4 | Human | Lysophospholipid (S1P) | A | pEC50 | 7.17 | 7.62 | 8.07 | Guide to Pharmacology |
| S1P5 | S1PR5 | Human | Lysophospholipid (S1P) | A | pEC50 | 7.4 | 8.15 | 8.9 | Guide to Pharmacology |
| GPR3 | GPR3 | Human | A orphans | A | pEC50 | 7.1 | 7.4 | 7.7 | Guide to Pharmacology |
| GPR12 | GPR12 | Human | A orphans | A | pEC50 | 5.51 | 6.24 | 6.97 | Guide to Pharmacology |
| GPR63 | GPR63 | Human | A orphans | A | pEC50 | 6.1 | 6.14 | 6.18 | Guide to Pharmacology |
| P2RY10 | P2Y10 | Human | A orphans | A | pEC50 | 7.3 | 7.3 | 7.3 | Guide to Pharmacology |
| S1P3 | S1PR3 | Mouse | Lysophospholipid (S1P) | A | pEC50 | 8.64 | 8.64 | 8.64 | Guide to Pharmacology |
| S1P4 | S1PR4 | Mouse | Lysophospholipid (S1P) | A | pEC50 | 7.12 | 7.12 | 7.12 | Guide to Pharmacology |
| S1P2 | S1PR2 | Mouse | Lysophospholipid (S1P) | A | pEC50 | 8.7 | 8.7 | 8.7 | Guide to Pharmacology |
| S1P5 | S1PR5 | Mouse | Lysophospholipid (S1P) | A | pEC50 | 7.8 | 7.85 | 7.9 | Guide to Pharmacology |
| GPR6 | GPR6 | Mouse | A orphans | A | pEC50 | 7.25 | 7.46 | 7.66 | Guide to Pharmacology |
| S1P1 | S1PR1 | Mouse | Lysophospholipid (S1P) | A | pEC50 | 8.85 | 8.85 | 8.85 | Guide to Pharmacology |
| S1P5 | S1PR5 | Human | Lysophospholipid (S1P) | A | pEC50 | 6.92 | 8.33 | 9.7 | ChEMBL |
| S1P5 | S1PR5 | Human | Lysophospholipid (S1P) | A | pIC50 | 8.51 | 8.79 | 9.26 | ChEMBL |
| S1P4 | S1PR4 | Human | Lysophospholipid (S1P) | A | pEC50 | 6.57 | 7.23 | 8.1 | ChEMBL |
| S1P4 | S1PR4 | Human | Lysophospholipid (S1P) | A | pIC50 | 6.82 | 7.84 | 8.98 | ChEMBL |
| S1P2 | S1PR2 | Human | Lysophospholipid (S1P) | A | pIC50 | 8.44 | 8.99 | 9.64 | ChEMBL |
| S1P2 | S1PR2 | Human | Lysophospholipid (S1P) | A | pEC50 | 7.36 | 8.39 | 9.15 | ChEMBL |
| S1P3 | S1PR3 | Human | Lysophospholipid (S1P) | A | pEC50 | 7.1 | 8.64 | 9.7 | ChEMBL |
| S1P3 | S1PR3 | Human | Lysophospholipid (S1P) | A | pIC50 | 9.04 | 9.5 | 10.4 | ChEMBL |
| S1P1 | S1PR1 | Human | Lysophospholipid (S1P) | A | pEC50 | 7.6 | 8.69 | 10.57 | ChEMBL |
| S1P1 | S1PR1 | Human | Lysophospholipid (S1P) | A | pIC50 | 8.85 | 9.19 | 9.8 | ChEMBL |